Our lead RAF program, KIN 2787 is a small molecule kinase inhibitor targeting specific classes of BRAF kinase alterations (Class II and Class III) that characterize subsets of melanoma, lung cancer, and other solid tumors. As a pan-RAF kinase inhibitor, KIN-2787 inhibits CRAF, a critical effector of oncogenic signaling in NRAS-mutant melanoma. While three BRAF targeted kinase inhibitor drugs targeting the Class I BRAF alterations have been approved by the FDA, no targeted therapies have been approved for Class II or Class III BRAF alteration-driven cancers or NRAS-mutant driven melanoma Patients with Class II or Class III BRAF alterations and NRAS-mutant melanoma do not respond to existing approved targeted therapies, have few treatment options available to them, and consequently have a poor prognosis. Initially, we plan to develop KIN-2787 for the treatment of patients with melanoma and non-small cell lung cancer (NSCLC) subpopulations with Class II or Class III BRAF alterations that include specific BRAF point mutations (other than BRAF V600E), BRAF insertions/deletions (indels) and BRAF gene fusion events as well as for the treatment of patients with NRAS-mutant melanoma. We expect that KIN-2787 may provide substantial clinical benefit to these cancer patients who are inadequately served by current therapies. We are currently evaluating the safety and tolerability of KIN-2787 in a first-in-human dose-escalation study in adults with BRAF-mutated advanced or metastatic solid tumors and NRAS-mutated advanced or metastatic melanoma both as a monotherapy and in combination with binimetinib for NRAS-mutant melanoma (KN-8701). More information can be found on ClinicalTrials.gov at: https://www.clinicaltrials.gov/ct2/show/NCT04913285